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Заболевание было описано советским неврологом Николаем Ивановичем Иценко и американским врачом Харви Уильямом Кушингом независимо друг от друга, отсюда название [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). \n\nПри подозрении на болезнь необходимо обратиться к эндокринологу [1](https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/).\n\n\n\n## Причины\nЧаще всего причиной гиперпродукции гормонов становится **опухоль гипофиза (аденома)**, стимулирующая выработку адренокортикотропного гормона (АКТГ), либо **опухоли самих надпочечников**, продуцирующих чрезмерное количество кортизола [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). Также выделяют **лекарственную форму** болезни, возникающую при длительном приёме глюкокортикоидных препаратов [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091).\n\n## Симптомы\nКлинические проявления болезни разнообразны и зависят от длительности и степени выраженности гиперфункции кортизола [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). Некоторые симптомы: \n* центральное ожирение («лунообразное лицо», жировые отложения в области живота и верхней части спины) [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* красные растяжки на коже (стрии) [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* повышенная утомляемость [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* слабость мышц конечностей [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* нарушения углеводного обмена вплоть до сахарного диабета [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* артериальная гипертензия [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* психоэмоциональные расстройства (депрессия, раздражительность, тревожность) [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091); \n* изменения кожи (акне, истончение кожных покровов, лёгкая травматичность сосудов) [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). \n\nПри прогрессировании заболевания развиваются остеопороз, повышенная ломкость костей, нарушение менструального цикла у женщин и снижение либидо у мужчин [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091).\n\n## Диагностика\nДля постановки диагноза проводят: \n* **Анализ крови и мочи на кортизол** — выявляет избыток гормона [1](https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/). \n* **Дексаметазоновый тест** — определяет источник гиперкортицизма [1](https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/). \n* **Анализ на АКТГ** — помогает различить надпочечниковую и гипофизарную формы заболевания [1](https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/). \n* **МРТ гипофиза, КТ надпочечников** — выявляют опухоли [1](https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/).\n\n## Лечение\nЛечение болезни Иценко-Кушинга направлено на устранение первопричины и нормализацию выработки кортизола [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). Методы терапии различаются в зависимости от формы заболевания [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091): \n* **Хирургическое вмешательство** — удаление аденомы гипофиза или надпочечника — основной метод в большинстве случаев [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). \n* **Медикаментозная терапия** — назначение препаратов, подавляющих продукцию кортизола (пасиреотид, каберголин, мифепристон и др.) — показано при невозможности оперативного вмешательства или подготовке к нему [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091). \n* **Радиотерапия** — лучевое воздействие на область гипофиза иногда используют в качестве дополнительного метода лечения после хирургического удаления опухоли [2](https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091).","linksData":[{"sourceId":1,"url":"https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/","shownUrl":"https://zdravclinic.ru/bolezni/sindrom-icenko-kushinga/","title":"Синдром Иценко-Кушинга: диагностика и лечение в Москве","shortUrl":"zdravclinic.ru","isTranslated":false,"description":"","greenUrl":"zdravclinic.ru"},{"sourceId":2,"url":"https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091","shownUrl":"https://Megapteka.ru/specials/bolezn-icenko-kushinga-6091","title":"Болезнь Иценко-Кушинга: Причины, симптомы, лечение, профилактика","shortUrl":"Megapteka.ru","isTranslated":false,"description":"","greenUrl":"Megapteka.ru"},{"sourceId":3,"url":"https://www.smclinic.ru/diseases/sindrom-kushinga/","shownUrl":"https://www.smclinic.ru/diseases/sindrom-kushinga/","title":"Синдром Иценко-Кушинга – что это, симптомы, диагностика, причины и лечение в «СМ-Клиника»","shortUrl":"smclinic.ru","isTranslated":false,"description":"","greenUrl":"smclinic.ru"},{"sourceId":4,"url":"https://stolichki.ru/clubs/health/diseases_with_a_name/sindrom-icenko-kushinga","shownUrl":"https://stolichki.ru/clubs/health/diseases_with_a_name/sindrom-icenko-kushinga","title":"Синдром Иценко-Кушинга: причины, симптомы и лечение","shortUrl":"stolichki.ru","isTranslated":false,"description":"","greenUrl":"stolichki.ru"},{"sourceId":5,"url":"https://www.gosmed.ru/lechebnaya-deyatelnost/spravochnik-zabolevaniy/endokrinologiya-bolezny/sindrom-i-bolezn-kushinga/","shownUrl":"https://www.gosmed.ru/lechebnaya-deyatelnost/spravochnik-zabolevaniy/endokrinologiya-bolezny/sindrom-i-bolezn-kushinga/","title":"Эндокринология: Синдром и болезнь Кушинга - 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