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Это приводит к повреждению костного мозга, костей, почек, нарушению работы иммунной системы [1](https://yandex.ru/medicine/disease/mielomnaja-bolezn)[2](https://Megapteka.ru/specials/simptomy-i-lechenie-4291). \n\nЗаболевание чаще диагностируют в пожилом возрасте, средний возраст пациентов — 70 лет [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/). У взрослых моложе 40 лет миеломная болезнь встречается крайне редко [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/).\n\n\n\n## Причины\nТочные причины миеломной болезни неизвестны [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/)[6](https://gemotest.ru/info/spravochnik/zabolevaniya/mielomnaya-bolezn/). Некоторые факторы, которые повышают риск: \n* воздействие токсических веществ и радиации [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/); \n* состояние иммунодефицита [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/); \n* генетические мутации и хромосомные аномалии [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/); \n* наследственная предрасположенность — миеломная болезнь у близких родственников [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/).\n\n## Симптомы\nПроявления миеломной болезни вариабельны, не существует двух одинаковых пациентов со схожей клинической картиной [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/). Некоторые симптомы: \n* **Очаги разрушения костей** — их обнаруживают в позвоночнике, костях таза, грудине, в длинных костях конечностей [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/). Проявляются болями в костях и их деформацией, иногда возможны спонтанные переломы без видимой внешней причины [4](https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/). \n* **Анемия** — снижение уровня эритроцитов в крови приводит к утомляемости, слабости и бледности кожных покровов [10](https://www.euroonco.ru/onkogematologiya/mieloma). \n* **Почечная недостаточность** — накопление парапротеинов в почках может нарушать их функцию, что проявляется уменьшением объёма выделяемой мочи, отёками и повышением уровня креатинина в крови [10](https://www.euroonco.ru/onkogematologiya/mieloma). \n* **Повышенный риск инфекций** — снижение иммунной защиты из-за нарушения функции нормальных плазматических клеток приводит к частым бактериальным и вирусным инфекциям [10](https://www.euroonco.ru/onkogematologiya/mieloma).\n\n## Диагностика\nДиагностика миеломной болезни включает комплекс анализов и исследований [10](https://www.euroonco.ru/onkogematologiya/mieloma). Некоторые методы: \n* **Анализы крови** — обнаружение моноклональных иммуноглобулинов или парапротеинов, измерение уровня кальция, креатинина [10](https://www.euroonco.ru/onkogematologiya/mieloma). \n* **Анализ мочи** — поиск белка Бенс-Джонса, который представляет собой лёгкие цепи иммуноглобулинов и выделяется в моче у примерно 70% пациентов с миеломой [10](https://www.euroonco.ru/onkogematologiya/mieloma). \n* **Биопсия и аспирация костного мозга** — позволяет оценить процентное содержание плазматических клеток в костном мозге и выявить наличие миеломных клеток [10](https://www.euroonco.ru/onkogematologiya/mieloma).\n\n## Лечение\n**Миеломная болезнь неизлечима** [1](https://yandex.ru/medicine/disease/mielomnaja-bolezn). Лечение продолжительное, его цель — достижение ремиссии [1](https://yandex.ru/medicine/disease/mielomnaja-bolezn). Некоторые методы: \n* **Химиотерапия** — выбор противоопухолевых препаратов зависит от стадии заболевания, возраста больного, состояния почек [11](https://www.invitro.ru/library/bolezni/34060/). \n* **Лучевая терапия** — метод подавления очагов миеломы крови и костной ткани [13](https://uteka.ru/articles/bolezni/mieloma/). \n* **Трансплантация костного мозга** — используется при множественной форме заболевания [13](https://uteka.ru/articles/bolezni/mieloma/). \n* **Симптоматическое лечение** — помогает облегчить выраженность конкретных проявлений патологии [1](https://yandex.ru/medicine/disease/mielomnaja-bolezn).","linksData":[{"sourceId":1,"url":"https://yandex.ru/medicine/disease/mielomnaja-bolezn","shownUrl":"https://yandex.ru/medicine/disease/mielomnaja-bolezn","title":"Миеломная болезнь - симптомы, причины и лечение","shortUrl":"yandex.ru","isTranslated":false,"description":"","greenUrl":"yandex.ru"},{"sourceId":2,"url":"https://Megapteka.ru/specials/simptomy-i-lechenie-4291","shownUrl":"https://Megapteka.ru/specials/simptomy-i-lechenie-4291","title":"Миеломная болезнь симптомы и лечение: Клинические рекомендации","shortUrl":"Megapteka.ru","isTranslated":false,"description":"","greenUrl":"Megapteka.ru"},{"sourceId":3,"url":"https://doct.ru/articles/mielomnaya-bolezn.html","shownUrl":"https://doct.ru/articles/mielomnaya-bolezn.html","title":"Миеломная болезнь: причины, симптомы и лечение","shortUrl":"doct.ru","isTranslated":false,"description":"","greenUrl":"doct.ru"},{"sourceId":4,"url":"https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/","shownUrl":"https://www.gmshospital.ru/diseases/mnozhestvennaya-mieloma/","title":"Множественная миелома: симптомы, причины, диагностика и лечение миеломной болезни","shortUrl":"gmshospital.ru","isTranslated":false,"description":"","greenUrl":"gmshospital.ru"},{"sourceId":5,"url":"https://lapino2.ru/napravleniya/onkogematologiya/mieloma/","shownUrl":"https://lapino2.ru/napravleniya/onkogematologiya/mieloma/","title":"Миелома: признаки, симптомы, лечение и прогнозы","shortUrl":"lapino2.ru","isTranslated":false,"description":"","greenUrl":"lapino2.ru"},{"sourceId":6,"url":"https://gemotest.ru/info/spravochnik/zabolevaniya/mielomnaya-bolezn/","shownUrl":"https://gemotest.ru/info/spravochnik/zabolevaniya/mielomnaya-bolezn/","title":"Миеломная болезнь - симптомы, профилактика и лечение","shortUrl":"gemotest.ru","isTranslated":false,"description":"","greenUrl":"gemotest.ru"},{"sourceId":7,"url":"https://onco.rehab/publikacii/stati/poleznye-materialy/mielomnaya-bolezn-prichiny-simptomy-diagnostika-i-lechenie/","shownUrl":"https://onco.rehab/publikacii/stati/poleznye-materialy/mielomnaya-bolezn-prichiny-simptomy-diagnostika-i-lechenie/","title":"Миелома – симптомы, стадии, диагностика и способы лечения этого онкологического заболевания","shortUrl":"onco.rehab","isTranslated":false,"description":"","greenUrl":"onco.rehab"},{"sourceId":8,"url":"https://MedPortal.ru/enc/oncology/leicosis/mielomnaya-bolezn/","shownUrl":"https://MedPortal.ru/enc/oncology/leicosis/mielomnaya-bolezn/","title":"Миеломная болезнь. 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