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Тромбообразование — процесс формирования сгустка крови в местах повреждения сосудов, но при тромбофилии механизм свёртывания «включается» без достаточных оснований и работает чрезмерно активно [1](https://life-reproduction.ru/stat-i/analiz-na-trombofiliyu-pri-planirovanii-beremennosti/)[13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). Это может привести к частичному или полному перекрытию просвета сосудов, нарушению кровотока, кислородному голоданию тканей и опасным осложнениям [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n\nТромбофилия не является заболеванием как таковым, а представляет собой состояние, которое в сочетании с факторами риска увеличивает вероятность возникновения тромбов [4](https://helix.ru/kb/item/740).\n\n\n\n## Причины\n* **Наследственная (первичная) тромбофилия** — развивается на фоне генетических мутаций, передающихся по наследству [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). Например, дефицит протеина C, недостаток протеина S, дефицит антитромбина III [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n* **Приобретённая (вторичная) тромбофилия** — возникает в течение жизни под воздействием различных факторов: аутоиммунных заболеваний, приёма некоторых лекарств, онкологических заболеваний, длительной иммобилизации (например, после операций) и других [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n\nЧасто для развития тромбоза требуется сочетание нескольких факторов [8](https://ProBolezny.ru/trombofiliya/).\n\n## Симптомы\n**На ранних этапах** тромбофилия может протекать бессимптомно [2](https://www.smclinic.ru/diseases/trombofiliya/)[13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). Человек может годами не подозревать о наличии тромбофилии, пока не случится первый эпизод тромбоза [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n\n**Некоторые возможные клинические проявления**: \n* отёк, боль, покраснение и чувство тяжести в ногах — признаки тромбоза глубоких вен [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/); \n* плотные участки под кожей, покраснение, жар — поверхностный венозный тромбоз [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/); \n* одышка, боль в груди, кашель с кровью — возможная тромбоэмболия лёгочной артерии [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n\nВ случае отрыва тромба возникает риск тромбоэмболии — крайне опасного состояния, при котором тромб попадает в лёгочную артерию или другие жизненно важные сосуды [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/).\n\n## Диагностика\n**Диагностический процесс начинается с осмотра врача и сбора анамнеза** [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). Могут назначить: \n* лабораторные исследования: общий анализ крови, коагулограмму, определение уровня фибриногена и D-димера, генетические тесты на мутации [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/); \n* инструментальные методы: ультразвуковую допплерографию сосудов нижних конечностей, флебографию (рентген с контрастом), КТ или МРТ — для диагностики тромбов в малом тазу, грудной клетке или мозге [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/).\n\n## Лечение\n**Лечение подбирается индивидуально** — на основании формы, выраженности, наличия тромбов и других факторов риска [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). **Цели терапии**: профилактика тромбозов и тромбоэмболий, устранение уже сформированных тромбов, снижение риска рецидивов [13](https://emirmed.kz/ru/articles/trombofiliia-diagnoz-ili-prigovor/). \n\n**Некоторые методы лечения**: \n* **Антикоагулянтная терапия** — применяются препараты, которые уменьшают свёртываемость крови [16](https://slavutich.su/diseases/trombofiliya/). \n* **Тромболитическая терапия** — в случаях, когда тромб уже образовался, используют препараты, которые помогают растворить сгусток крови [16](https://slavutich.su/diseases/trombofiliya/). \n* **Хирургическое вмешательство** — в некоторых случаях, например, при тромбозах крупных вен или артерий, требуется хирургическое удаление тромба [16](https://slavutich.su/diseases/trombofiliya/).","linksData":[{"sourceId":1,"url":"https://life-reproduction.ru/stat-i/analiz-na-trombofiliyu-pri-planirovanii-beremennosti/","shownUrl":"https://life-reproduction.ru/stat-i/analiz-na-trombofiliyu-pri-planirovanii-beremennosti/","title":"Анализ на тромбофилию при планировании беременности | Центр репродукции «Линия жизни» в Москве","shortUrl":"life-reproduction.ru","isTranslated":false,"description":"","greenUrl":"life-reproduction.ru"},{"sourceId":2,"url":"https://www.smclinic.ru/diseases/trombofiliya/","shownUrl":"https://www.smclinic.ru/diseases/trombofiliya/","title":"Тромбофилия – симптомы, причины, признаки, диагностика и лечение в «СМ-Клиника»","shortUrl":"smclinic.ru","isTranslated":false,"description":"","greenUrl":"smclinic.ru"},{"sourceId":3,"url":"https://klinikakrovi.ru/nasledstvennaya-trombofiliya/","shownUrl":"https://klinikakrovi.ru/nasledstvennaya-trombofiliya/","title":"Наследственная тромбофилия | Полезные статьи Клиники крови","shortUrl":"klinikakrovi.ru","isTranslated":false,"description":"","greenUrl":"klinikakrovi.ru"},{"sourceId":4,"url":"https://helix.ru/kb/item/740","shownUrl":"https://helix.ru/kb/item/740","title":"Тромбофилия","shortUrl":"helix.ru","isTranslated":false,"description":"","greenUrl":"helix.ru"},{"sourceId":5,"url":"https://www.invitro.ru/library/bolezni/26816/","shownUrl":"https://www.invitro.ru/library/bolezni/26816/","title":"Тромбофилия - причины появления, симптомы заболевания, диагностика и способы лечения","shortUrl":"invitro.ru","isTranslated":false,"description":"","greenUrl":"invitro.ru"},{"sourceId":6,"url":"https://medastrum.ru/poleznaya-informatsiya/trombofiliya","shownUrl":"https://medastrum.ru/poleznaya-informatsiya/trombofiliya","title":"Тромбофилия - что это за болезнь","shortUrl":"medastrum.ru","isTranslated":false,"description":"","greenUrl":"medastrum.ru"},{"sourceId":7,"url":"https://meddynasty.ru/uslugi/gematolog/lechenie-nasledstvennoj-trombofilii","shownUrl":"https://meddynasty.ru/uslugi/gematolog/lechenie-nasledstvennoj-trombofilii","title":"Наследственная тромбофилия - лечение, обследование и диагностика в СПб и Всеволожске","shortUrl":"meddynasty.ru","isTranslated":false,"description":"","greenUrl":"meddynasty.ru"},{"sourceId":8,"url":"https://ProBolezny.ru/trombofiliya/","shownUrl":"https://ProBolezny.ru/trombofiliya/","title":"Тромбофилия","shortUrl":"ProBolezny.ru","isTranslated":false,"description":"","greenUrl":"ProBolezny.ru"},{"sourceId":9,"url":"https://www.medzhencentre.ru/article/trombofiliya/","shownUrl":"https://www.medzhencentre.ru/article/trombofiliya/","title":"Тромбофилия: маркеры, симптомы, признаки – как лечить гематогенную, мультигенную тромбофилию — Медицинский женский центр в Москве","shortUrl":"medzhencentre.ru","isTranslated":false,"description":"","greenUrl":"medzhencentre.ru"},{"sourceId":10,"url":"https://mag.103.by/zdorovje/112543-trombofilija-vidy-i-osobennosti-zabolevanija-prichiny-simptomy-lechenije/","shownUrl":"https://mag.103.by/zdorovje/112543-trombofilija-vidy-i-osobennosti-zabolevanija-prichiny-simptomy-lechenije/","title":"Тромбофилия - что это за болезнь, причины, симптомы, лечение","shortUrl":"mag.103.by","isTranslated":false,"description":"","greenUrl":"mag.103.by"},{"sourceId":11,"url":"https://medcentr-Sochi.ru/flebolog/trombofiliya.html","shownUrl":"https://medcentr-Sochi.ru/flebolog/trombofiliya.html","title":"Тромбофилия: причины возникновения, симптомы и лечение у врача-флеболога в МКЦ «Проксима» (г. 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